2. Metabolic Disease

Metabolic Disease

Metabolic Disease

Related Products

PDF 53.7 MB

Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N7203R
    N-Caffeoyl O-methyltyramine (Standard) 189307-47-9
    N-Caffeoyl O-methyltyramine (Standard) is the analytical standard of N-Caffeoyl O-methyltyramine. This product is intended for research and analytical applications. N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase (IC50 of 103.58 μM).
    N-Caffeoyl O-methyltyramine (Standard)
  • HY-N7206R
    5-O-Methylvisamminol (Standard) 80681-42-1
    5-O-Methylvisamminol (Standard) is the analytical standard of 5-O-Methylvisamminol. This product is intended for research and analytical applications. 5-O-Methylvisamminol, a (furo) chromone identified in the extract of T. glauca, has a limited occurrence in the plant kingdom. 5-O-Methylvisamminol is useful in (chemical) phylogeny and is a possible excellent chemotaxonomic marker (family and/or subfamily level) for Apiaceae.
    5-O-Methylvisamminol (Standard)
  • HY-N7247R
    Thiochrome (Standard) 92-35-3
    Thiochrome (Standard) is the analytical standard of Thiochrome. This product is intended for research and analytical applications. Thiochrome, a natural oxidation product and metabolite of thiamine, is a selective M4 muscarinic receptor of acetylcholine (ACh) affinity enhancer. Thiochrome has neutral cooperativity with ACh at M1 to M3 receptors.
    Thiochrome (Standard)
  • HY-N7264R
    7α-Hydroxycholesterol (Standard) 566-26-7 98%
    7α-Hydroxycholesterol is a cholesterol oxide and can serve as a biomarker for oxidative stress and lipid peroxidation. 7α-Hydroxycholesterol has cytotoxic and pro-inflammatory activities. 7α-Hydroxycholesterol can also inhibit sterol synthesis and reduce the activity of HMG-CoA reductase. 7α-Hydroxycholesterol can be used in the research of diseases such as diabetes and atherosclerosis.
    7α-Hydroxycholesterol (Standard)
  • HY-N7272R
    Cirsimarin (Standard) 13020-19-4
    Cirsimarin (Standard) is the analytical standard of Cirsimarin. This product is intended for research and analytical applications. Cirsimarin is a potent antilipogenic flavonoid isolated from Microtea debilis. Cirsimarin exerts potent antilipogenic effect and decreases adipose tissue deposition in mice. The lipolytic activity of Cirsimarin resulting from both its antagonist activity on adenosin A1 receptor and its inhibitory effect on phosphodiesterase.
    Cirsimarin (Standard)
  • HY-N7347R
    (-)-Hydroxycitric acid lactone (Standard) 27750-13-6
    (-)-Hydroxycitric acid lactone (Standard) is the analytical standard of (-)-Hydroxycitric acid lactone. This product is intended for research and analytical applications. (-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis.
    (-)-Hydroxycitric acid lactone (Standard)
  • HY-N7393R
    Isomalt (Standard) 64519-82-0 98%
    Isomalt (Standard) is the analytical standard of Isomalt. This product is intended for research and analytical applications. Isomalt (Palatinitol), a well-tolerated, non-toxic polyol and a protein-stabilizing excipient, stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying, and performs better during storage. Isomalt is traditionally used as a sweetening agent in the food industry and as a tabletting excipient for pharmaceutical purposes.
    Isomalt (Standard)
  • HY-N7433R
    4,6-O-Ethylidene-α-D-glucose (Standard) 13224-99-2
    4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose), a glucose derivative, is a competitive exofacial binding-site inhibitor on glucose transporter 1 (GLUT1) with a Ki of 12 mM for wild-type 2-deoxy-D-glucose transport.
    4,6-O-Ethylidene-α-D-glucose (Standard)
  • HY-N7503R
    Psoralenoside (Standard) 905954-17-8 98%
    Psoralenoside is a benzofuran glycoside from Psoralea corylifolia. Psoralenoside exhibits high binding affinities against histaminergic H1, calmodulin, and voltage-gated L-type calcium channels (E-value≥-6.5 Kcal/mol). Psoralenoside shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity.
    Psoralenoside (Standard)
  • HY-N7690R
    3,5,7,3′,4′-Pentamethoxyflavone (Standard) 1247-97-8 98%
    3,5,7,3’,4’-Pentamethoxyflavone is a Ca2+ channel inhibitor. 3,5,7,3’,4’-Pentamethoxyflavone can protect DNA from oxidative damage. 3,5,7,3’,4’-Pentamethoxyflavone can induce relaxation of the human corpus cavernosum through calcium mobilization-related mechanisms. 3,5,7,3’,4’-Pentamethoxyflavone can promote the expression of eNOS and cystathionine gamma lyase CSE proteins in middle-aged male rats and regulate vascular function. 3,5,7,3’,4’-Pentamethoxyflavone can be used in research related to diabetes and cardiovascular diseases.
    3,5,7,3′,4′-Pentamethoxyflavone (Standard)
  • HY-N7697C
    Chitohexaose hexahydrochloride 127171-88-4
    Chitohexaose hexahydrochloride is a small molecular polysaccharide. Chitohexaose hexahydrochloride inhibits the binding of AgW to TLR4. Chitohexaose hexahydrochloride upregulates IL-10, inhibits LPS-induced upregulation of ROS, induces alternative activation of macrophages/monocytes, and suppresses LPS-induced production of TNF-α, IL-1β and IL-6. Chitohexaose hexahydrochloride reverses the mortality of mice challenged with APAP or LPS. Chitohexaose hexahydrochloride can be used in research related to Acetaminophen (HY-66005)-induced hepatotoxicity and endotoxemia.
    Chitohexaose hexahydrochloride
  • HY-N7832R
    Petunidin-3-O-glucoside chloride (Standard) 6988-81-4
    Petunidin-3-O-glucoside (chloride) (Standard) is the analytical standard of Petunidin-3-O-glucoside (chloride). This product is intended for research and analytical applications. Petunidin-3-O-glucoside chloride is a flavonoid isolated from Phaseolus vulgaris L. seed, has antioxidant activity
    Petunidin-3-O-glucoside chloride (Standard)
  • HY-N8438S
    Methyl tetracosanoate-d4 2692624-16-9 98%
    Methyl tetracosanoate-d4 (Methyl lignocerate-d4) is deuterium labeled Methyl tetracosanoate. Methyl tetracosanoate (Methyl lignocerate) is a fatty acid methyl ester with anti-diabetic activity.
    Methyl tetracosanoate-d4
  • HY-N8518R
    Malabaricone C (Standard) 63335-25-1 98%
    Malabaricone C is an orally active and noncompetitive sphingomyelin synthase (SMS) inhibitor with IC50 values of 3 μM and 1.5 μM for SMS 1 and SMS 2, respectively. Malabaricone C reduces body weight gain, improves glucose tolerance, and decreases lipid accumulation in the liver, showing significant prevention of high fat diet-induced fatty liver in mice. Malabaricone C has anti-inflammatory effects, which is found in the fruits of Myristica cinnamomea King. Malabaricone C is promising for research of obesity and immunological disorders caused due to hyper-activation of T-cells.
    Malabaricone C (Standard)
  • HY-N9153A
    Guaiacylglycerol-8-O-4'-(sinapyl alcohol) ether 905726-70-7 98%
    Guaiacylglycerol-8-O-4'-(sinapyl alcohol) ether is a DGAT1 inhibitor with an IC50 of 92.7 μM and can be extracted from Eleutherococcus senticosus. Guaiacylglycerol-8-O-4'-(sinapyl alcohol) ether can be utilized in research related to type II diabetes and obesity.
    Guaiacylglycerol-8-O-4'-(sinapyl alcohol) ether
  • HY-N9435R
    28-Homobrassinolide (Standard) 82373-95-3 98%
    28-Homobrassinolide (Standard) is the analytical standard of 28-Homobrassinolide (HY-N9435). This product is intended for research and analytical applications. 28-Homobrassinolide is a phytosteroid. 28-Homobrassinolide can be used for the research of cholesterol and glucose homeostasis.
    28-Homobrassinolide (Standard)
  • HY-N9483R
    7-Keto-DHEA (Standard) 566-19-8
    7-Keto-DHEA (Standard) (7-Oxo-DHEA (Standard)) is the analytical standard of 7-Keto-DHEA (HY-N9483). This product is intended for research and analytical applications. 7-Keto-DHEA binds to GABA Receptor, and reduces the ethanol intake in rats. 7-Keto-DHEA exhibits potential in investigation of alcohol dependence disorders.
    7-Keto-DHEA (Standard)
  • HY-P0058S
    Pramlintide-(Ala-13C3,15N) 98%
    Pramlintide-(Ala-13C3,15N) is the 13C- and 15N-labeled Pramlintide. Pramlintide is a polypeptide analogue of human amylin. Pramlintide, an antidiabetic agent, is antineoplastic in colorectal cancer.
    Pramlintide-(Ala-13C3,15N)
  • HY-P0119S
    Lixisenatide (Leu-13C6,15N) TFA 98%
    Lixisenatide (Leu-13C6,15N) TFA is the 13C- and 15N-labeled Lixisenatide (HY-P0119). Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist. Lixisenatide inhibits the inflammatory response through down regulation of pro-inflammatory cytokines, and suppresses of the Akt-MEK1/2 signaling pathway. Lixisenatide can inhibit oxidative stress, mitochondrial dysfunction and apoptosis. Lixisenatide can be used for the researches of inflammation, metabolic disease, neurological disease and cardiovascular disease, such as rheumatoid arthritis, diabetes, Alzheimer's disease and atherosclerosis.
    Lixisenatide (Leu-13C6,15N) TFA
  • HY-P10673
    KwFwLL-NH2 942266-38-8 98%
    KwFwLL-NH2, a hexapeptide, is a ghrelin receptor ligand. KwFwLL-NH2 can act as a specific inverse agonist at the ghrelin receptor but with moderate potency (EC50=45.6 nM).
    KwFwLL-NH2
Cat. No. Product Name / Synonyms Application Reactivity